PPIRE11958

Target Protein Information
Protein_Name Circumsporozoite protein
Protein_Sequence EALFQEYQCYGSSSNTRVLNELNYDNAGTNLYNELEMNYYGKQENWYSLKKNSRSLGENDDGNNNNGDNGREGKDEDKRDGNNEDNEKLRKPKHKKLKQPADGNPDPNANPNVDPNANPNVDPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNKNNQGNGQGHNMPNDPNRNVDENANGNNAVKNNNNEEPSDQHIEKYL
Organism_Source Plasmodium falciparum (isolate le5)
Functional_Classification Circumsporozoite protein
Cellular_Localization Extracellular
Gene_Names CSP
UniProt_ID P05691
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide 21
Peptide_Sequence NPDPNANPNVDPNAN
Peptide_Length 15
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1562.57
Aliphatic_Index 32.66667
Aromaticity 0.00000
Average_Rotatable_Bonds 2.80000
Charge_at_pH_7 -2.00112
Isoelectric_Point 3.49188
Number_of_Hydrogen_Bond_Acceptors 24
Number_of_Hydrogen_Bond_Donors 20
Topological_Polar_Surface_Area 768.70000
X_logP_energy -12.89210
Interaction Information
Affinity KD=7.5 nM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 6B5M
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.
Release_Year 2018
PMID 29554083
DOI 10.1038/nm.4512