PPIRE11969

Target Protein Information
Protein_Name Gag polyprotein
Protein_Sequence MGASASVLTGSKLDAWEQIRLKPGSKKKYRLKHLVWASRELERFACNPELLETAEGNEKLLQQLEPALKTGSDSLQSLWNAIVVLWCVHNRYKIGDTQQAIQKLKEVMGSRKSADAAKEDTSARQAGQNYPIVSNAQGQMVHQAISPRTLNAWVKAVEEKAFNPEIIPMFMALSEGAISYDINTMLNAIGGHQGALQVLKEVINEEAVEWDRTHPPPVGPLPPGQIREPTGSDIAGTTSTQQEQIHWTTRPNQPIPVGDIYRKWIVLGLNKMVKMYSPVSILDIKQGPKEPFRDYVDRFYKTLRAEQATQEVKNWMTETLLVQNANPDCKQILKSLGPGATLEEMMVACQGVGGPTHKARVLAEAMATAQQDLKGGYTAVFMQRGQNPIRKGTIKCFNCGKEGHIARNCRAPRKKGCWKCGQEGHQMKDCRNGKQANFLGKYWPPGGTRPGNYVQRPAHPSAPPMEEEVKGQENQEQKGGPNELYPFASLKSLFGTDQ
Organism_Source Human immunodeficiency virus type 1 group O (isolate ANT70)
Functional_Classification capsid proteins
Cellular_Localization Cytoplasm
Gene_Names gag
UniProt_ID Q77372
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name CPSF6(313-327)
Peptide_Sequence PVLFPGQPFGQPPLG
Peptide_Length 15
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1550.82
Aliphatic_Index 71.33333
Aromaticity 0.13333
Average_Rotatable_Bonds 2.66667
Charge_at_pH_7 -0.00202
Isoelectric_Point 6.10000
Number_of_Hydrogen_Bond_Acceptors 18
Number_of_Hydrogen_Bond_Donors 14
Topological_Polar_Surface_Area 507.75000
X_logP_energy -2.70620
Interaction Information
Affinity KD=83 uM
Affinity_Assay Fluorescence Polarization
PDB_ID 4WYM
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title Structural basis of HIV-1 capsid recognition by PF74 and CPSF6.
Release_Year 2014
PMID 25518861
DOI 10.1073/pnas.1419945112