PPIRE12009
Target Protein Information
| Protein_Name | PHD finger protein 1 |
|---|---|
| Protein_Sequence | MAQPPRLSRSGASSLWDPASPAPTSGPRPRLWEGQDVLARWTDGLLYLGTIKKVDSAREVCLVQFEDDSQFLVLWKDISPAALPGEELLCCVCRSETVVPGNRLVSCEKCRHAYHQDCHVPRAPAPGEGEGTSWVCRQCVFAIATKRGGALKKGPYARAMLGMKLSLPYGLKGLDWDAGHLSNRQQSYCYCGGPGEWNLKMLQCRSCLQWFHEACTQCLSKPLLYGDRFYEFECCVCRGGPEKVRRLQLRWVDVAHLVLYHLSVCCKKKYFDFDREILPFTSENWDSLLLGELSDTPKGERSSRLLSALNSHKDRFISGREIKKRKCLFGLHARMPPPVEPPTGDGALTSFPSGQGPGGGVSRPLGKRRRPEPEPLRRRQKGKVEELGPPSAVRNQPEPQEQRERAHLQRALQASVSPPSPSPNQSYQGSSGYNFRPTDARCLPSSPIRMFASFHPSASTAGTSGDSGPPDRSPLELHIGFPTDIPKSAPHSMTASSSSVSSPSPGLPRRSAPPSPLCRSLSPGTGGGVRGGVGYLSRGDPVRVLARRVRPDGSVQYLVEWGGGGIF |
| Organism_Source | Homo sapiens |
| Functional_Classification | histone methylation reader |
| Cellular_Localization | Nucleus |
| Gene_Names | PHF1 |
| UniProt_ID | O43189 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | H3(28-43)K36me2 |
|---|---|
| Peptide_Sequence | SAPATGGVKKPHRYP |
| Peptide_Length | 15 |
| Peptide_SMILES | CC(C)[C@H](NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@@H](N)CO)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)O |
| Chemical_Modification | K9=dimethylation |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1565.80 |
|---|---|
| Aliphatic_Index | 32.66667 |
| Aromaticity | 0.06667 |
| Average_Rotatable_Bonds | 3.00000 |
| Charge_at_pH_7 | 3.08745 |
| Isoelectric_Point | 10.90184 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 23 |
| Number_of_Hydrogen_Bond_Donors | 22 |
| Topological_Polar_Surface_Area | 647.66000 |
| X_logP_energy | -7.52883 |
Interaction Information
| Affinity | KD=19.3 uM |
|---|---|
| Affinity_Assay | Isothermal titration calorimetry |
| PDB_ID | 2M0O |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. |
| Release_Year | 2013 |
| PMID | 23273982 |
| DOI | 10.1016/j.molcel.2012.11.026 |