PPIRE12033

Target Protein Information
Protein_Name Protein Mdm4
Protein_Sequence MTSLASSSQLPGSCRTLPGEGTQVHPRAPLLQILKVAGAQEEVFTLKEVMHYLGQYIMMKQLYDKQRQHIVHCHDDPLGELLEVGSFSVKNPSPVYEMLKRNLVILNNSDAAKNLSVGKDSNESPSEDPGQVSSGSINSAQPLIAGSSSTGTTQSCSQRRPRDPDEDSSDGLPRSACKRPKLDVTLEEWDLSGLPWWFLGNLRSNYTRRSNGSTDIHTNQLSPGQDEDTAIVSDTTDDLWFLNEAESEQVSVEIKEAVLEQGSDGESPHEDEDTGKDSKDDGKMQEEQEEDSQCLSDDTDTEISTQDAWQCSECRKFNTPLQRYCMRCWALRKDWYKDCPRLVHSISVPDIPACSSRPERDEDEEEEDDDGIDMPDCLRTVSDPVVLPSHRVSRNIPSSSASSSKGKGPSQIHHHFQETSEGDSQDTLDMETEYQPEALLEPCKLCRVRPRNGNIIHGRTAHLITCFPCARKLHKFHAPCPGCGQVIQKVIKTFIA
Organism_Source Danio rerio
Functional_Classification ubiquitin ligases
Cellular_Localization Nucleus
Gene_Names mdm4
UniProt_ID Q7ZUW7
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name p53 peptide 1
Peptide_Sequence SQETFSDLWKLLPEN
Peptide_Length 15
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1806.99
Aliphatic_Index 78.00000
Aromaticity 0.13333
Average_Rotatable_Bonds 3.86667
Charge_at_pH_7 -1.99831
Isoelectric_Point 3.92755
Number_of_Hydrogen_Bond_Acceptors 25
Number_of_Hydrogen_Bond_Donors 25
Topological_Polar_Surface_Area 762.51000
X_logP_energy -6.36370
Interaction Information
Affinity KD=1.22 mM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 2Z5S
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Molecular basis for the inhibition of p53 by Mdmx.
Release_Year 2007
PMID 17938582
DOI 10.4161/cc.6.19.4740