PPIRE12099

Target Protein Information
Protein_Name Potassium voltage-gated channel subfamily A member 1
Protein_Sequence MTVMSGENADEASTAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTIHRIDNTTVIYTSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDLSRRSSSTISKSEYMEIEEDMNNSIAHYRQANIRTGNCTTADQNCVNKSKLLTDV
Organism_Source Mus musculus
Functional_Classification voltage-gated potassium channels
Cellular_Localization Plasma membrane
Gene_Names Kcna1
UniProt_ID P16388
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name A16-28
Peptide_Sequence XISSVCVSSYRGRKS
Peptide_Length 15
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)C(C)C)C(C)C
Chemical_Modification X1=norleucine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1585.80
Aliphatic_Index 64.66667
Aromaticity 0.06667
Average_Rotatable_Bonds 3.53333
Charge_at_pH_7 2.93486
Isoelectric_Point 10.45681
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 30
Topological_Polar_Surface_Area 741.92000
X_logP_energy -11.69846
Interaction Information
Affinity KD=36 uM
Affinity_Assay electrophysiology; whole-cell patch clamp
PDB_ID None
Type Ion channel modulator
Structure
Reference Information
Document_Type Research Articles
Title Studies on the blocking action of human Kv3.4 inactivation peptide variants in the mouse cloned Kv1.1 K+ channel.
Release_Year 1996
PMID 8910203
DOI 10.1113/jphysiol.1996.sp021672