PPIRE12106

Target Protein Information
Protein_Name AP-2 complex subunit mu
Protein_Sequence MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHVKRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFGYPQNSETGALKTFITQQGIKSQHQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGMKESQISAEIELLPTNDKKKWARPPISMNFEVPFAPSGLKVRYLKVFEPKLNYSDHDVIKWVRYIGRSGIYETRC
Organism_Source Homo sapiens
Functional_Classification adaptor proteins
Cellular_Localization Plasma membrane
Gene_Names AP2M1
UniProt_ID Q96CW1
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name PIPKIgamma-p90 tail peptide
Peptide_Sequence YFPTDERSWVYSPLH
Peptide_Length 15
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1897.08
Aliphatic_Index 45.33333
Aromaticity 0.26667
Average_Rotatable_Bonds 3.46667
Charge_at_pH_7 -0.91059
Isoelectric_Point 5.45418
Number_of_Hydrogen_Bond_Acceptors 25
Number_of_Hydrogen_Bond_Donors 26
Topological_Polar_Surface_Area 735.26000
X_logP_energy -4.30273
Interaction Information
Affinity KD=6 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 3H1Z
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title Molecular basis for association of PIPKI gamma-p90 with clathrin adaptor AP-2.
Release_Year 2010
PMID 19903820
DOI 10.1074/jbc.M109.074906