PPIRE12114

Target Protein Information
Protein_Name Karilysin
Protein_Sequence MKRFILLFFLSTIAIFKVYSQRLYDNGPLTGDNNYVLQGSKWNKTTLKYYIYNSSSHLTTTERENAIRSAFALWSDKSTLSFIQVYNPNQADIKIKWEKGNHGDGYPFDGNTGILAHAFYPPPAGGNYAGHLHFDGDENWSINGSGIDLITVAAHEIGHLLGIEHSNVSSALMYPYYTGIKRQLDNDDCLAVWDLYGYPFSISGPSSVCDQATYTVENLLSGATVQWSVSNPNIATINSSNGVLTCRGNGICEVRATINNSSVALTPLKICLGTPISQDITLTVESLNSNGTLCTDNPNAIMADHPGGNHLGYIREYEWRISNGWQIAHHPGDNGIYADHFIVTVIPLSPLPGSPTVSVRARSECGWGTWKEVQIPAVSCSRTISPFTLSPNPATDEVILQLMETDEVSGLSVLSTDRSAYEIQIWSGMRMLRSFRTNEPTFQISMTGLPAGLYFVRVVKNGQTYTQKLIKK
Organism_Source Tannerella forsythia (strain ATCC 43037 / JCM 10827 / CCUG 21028 A / KCTC 5666 / FDC 338)
Functional_Classification metallopeptidases
Cellular_Localization Extracellular
Gene_Names kly
UniProt_ID D0EM77
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SWFP
Peptide_Sequence SWFP
Peptide_Length 4
Peptide_SMILES N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 535.60
Aliphatic_Index 0.00000
Aromaticity 0.50000
Average_Rotatable_Bonds 2.75000
Charge_at_pH_7 -0.00202
Isoelectric_Point 6.10000
Number_of_Hydrogen_Bond_Acceptors 6
Number_of_Hydrogen_Bond_Donors 6
Topological_Polar_Surface_Area 177.85000
X_logP_energy 0.31790
Interaction Information
Affinity Ki=10.7 mM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID 4IN9
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structure of the catalytic domain of the Tannerella forsythia matrix metallopeptidase karilysin in complex with a tetrapeptidic inhibitor.
Release_Year 2013
PMID 23695557
DOI 10.1107/S1744309113007392