PPIRE12143
Target Protein Information
| Protein_Name | Hyccin |
|---|---|
| Protein_Sequence | MFTSEKGVVEEWLSEFKTLPETSLPNYATNLKDKSSLVSSLYKVIQEPQSELLEPVCHQLFEFYRSGEEQLLQFTLQFLPELIWCYLAVSASRNVHSSGCIEALLLGVYNLEIVDKQGHTKVLSFTIPSLSKPSVYHEPSSIGSMALTESALSQHGLSKVVYSGPHPQREMLTAQNRFEVLTFLLLCYNAALTYMPSVSLQSLCQICSRICVCGYPRQHVRKYKGISSRIPVSSGFMVQMLTGIYFAFYNGEWDLAQKALDDIIYRAQLELYPEPLLVANAIKASLPHGPMKSNKEGTRCIQVEITPTSSRISRNAVTSMSIRGHRWKRHGNTELTGQEELMEISEVDEGFYSRAASSTSQSGLSNSSHNCSNKPSIGKNHRRSGGSKTGGKEKETTGESCKDHFARKQTQRAQSENLELLSLKRLTLTTSQSLPKPSSHGLAKTAATVFSKSFEQVSGVTVPHNPSSAVGCGAGTDANRFSACSLQEEKLIYVSERTELPMKHQSGQQRPPSISITLSTD |
| Organism_Source | Homo sapiens |
| Functional_Classification | cell adhesion |
| Cellular_Localization | Nucleus |
| Gene_Names | HYCC1 |
| UniProt_ID | Q9BYI3 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | fStAx-3 |
|---|---|
| Peptide_Sequence | ENPEXILDSHVXRVM |
| Peptide_Length | 15 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCSC)C(=O)O)C(C)C)C(C)C |
| Chemical_Modification | X5=alpha-methyl-alkenyl amino acid; X12=alpha-methyl-alkenyl amino acid |
| Cyclization_Method | side chain-side chain cyclization; X5<->X12; other bonds |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Fitc |
| C-terminal_Modification | amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1652.84 |
|---|---|
| Aliphatic_Index | 90.66667 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.60000 |
| Charge_at_pH_7 | -1.90711 |
| Isoelectric_Point | 4.42146 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 24 |
| Number_of_Hydrogen_Bond_Donors | 24 |
| Topological_Polar_Surface_Area | 727.73000 |
| X_logP_energy | -7.58713 |
Interaction Information
| Affinity | KD=60 nM |
|---|---|
| Affinity_Assay | Fluorescence Polarization |
| PDB_ID | None |
| Type | antagonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Inhibition of oncogenic Wnt signaling through direct targeting of Beta-catenin. |
| Release_Year | 2012 |
| PMID | 23071338 |
| DOI | 10.1073/pnas.1208396109 |