PPIRE12144

Target Protein Information
Protein_Name Hyccin
Protein_Sequence MFTSEKGVVEEWLSEFKTLPETSLPNYATNLKDKSSLVSSLYKVIQEPQSELLEPVCHQLFEFYRSGEEQLLQFTLQFLPELIWCYLAVSASRNVHSSGCIEALLLGVYNLEIVDKQGHTKVLSFTIPSLSKPSVYHEPSSIGSMALTESALSQHGLSKVVYSGPHPQREMLTAQNRFEVLTFLLLCYNAALTYMPSVSLQSLCQICSRICVCGYPRQHVRKYKGISSRIPVSSGFMVQMLTGIYFAFYNGEWDLAQKALDDIIYRAQLELYPEPLLVANAIKASLPHGPMKSNKEGTRCIQVEITPTSSRISRNAVTSMSIRGHRWKRHGNTELTGQEELMEISEVDEGFYSRAASSTSQSGLSNSSHNCSNKPSIGKNHRRSGGSKTGGKEKETTGESCKDHFARKQTQRAQSENLELLSLKRLTLTTSQSLPKPSSHGLAKTAATVFSKSFEQVSGVTVPHNPSSAVGCGAGTDANRFSACSLQEEKLIYVSERTELPMKHQSGQQRPPSISITLSTD
Organism_Source Homo sapiens
Functional_Classification cell adhesion
Cellular_Localization Nucleus
Gene_Names HYCC1
UniProt_ID Q9BYI3
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name fStAx-2
Peptide_Sequence ENXPESIXSHVQSVM
Peptide_Length 15
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CCC(=O)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CCSC)C(=O)O)C(C)C)C(C)C
Chemical_Modification X3=alpha-methyl-alkenyl amino acid; X7=alpha-methyl-alkenyl amino acid
Cyclization_Method side chain-side chain cyclization; X3<->X7; other bonds
Linear/Cyclic Cyclic
N-terminal_Modification Fitc
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1570.69
Aliphatic_Index 64.66667
Aromaticity 0.00000
Average_Rotatable_Bonds 3.40000
Charge_at_pH_7 -1.90756
Isoelectric_Point 4.25427
Number_of_Hydrogen_Bond_Acceptors 25
Number_of_Hydrogen_Bond_Donors 23
Topological_Polar_Surface_Area 712.08000
X_logP_energy -10.12110
Interaction Information
Affinity KD=4 uM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Inhibition of oncogenic Wnt signaling through direct targeting of Beta-catenin.
Release_Year 2012
PMID 23071338
DOI 10.1073/pnas.1208396109