PPIRE12145
Target Protein Information
| Protein_Name | Tumor necrosis factor ligand superfamily member 13 |
|---|---|
| Protein_Sequence | MPASSPGHMGGSVREPALSVALWLSWGAVLGAVTCAVALLIQQTELQSLRREVSRLQRSGGPSQKQGERPWQSLWEQSPDVLEAWKDGAKSRRRRAVLTQKHKKKHSVLHLVPVNITSKADSDVTEVMWQPVLRRGRGLEAQGDIVRVWDTGIYLLYSQVLFHDVTFTMGQVVSREGQGRRETLFRCIRSMPSDPDRAYNSCYSAGVFHLHQGDIITVKIPRANAKLSLSPHGTFLGFVKL |
| Organism_Source | Mus musculus |
| Functional_Classification | TNF ligand superfamily |
| Cellular_Localization | Extracellular |
| Gene_Names | Tnfsf13 |
| UniProt_ID | Q9D777 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | 5.2 |
|---|---|
| Peptide_Sequence | GFDFCLWDGWCSVEK |
| Peptide_Length | 15 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)O)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | Side chain-side chain cyclization; C2<->C12; disulfide bond |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
|
|
|
Peptide Physicochemical
| Molecular_Weight | 1792.01 |
|---|---|
| Aliphatic_Index | 45.33333 |
| Aromaticity | 0.26667 |
| Average_Rotatable_Bonds | 3.60000 |
| Charge_at_pH_7 | -2.12359 |
| Isoelectric_Point | 3.87599 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 23 |
| Number_of_Hydrogen_Bond_Donors | 25 |
| Topological_Polar_Surface_Area | 660.45000 |
| X_logP_energy | -3.12110 |
Interaction Information
| Affinity | IC50=1 uM |
|---|---|
| Affinity_Assay | BIAcore competition assay |
| PDB_ID | None |
| Type | antagonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Multiple novel classes of APRIL-specific receptor-blocking peptides isolated by phage display. |
| Release_Year | 2010 |
| PMID | 19945466 |
| DOI | 10.1016/j.jmb.2009.11.041 |