PPIRE12189

Target Protein Information
Protein_Name Chromobox protein homolog 7
Protein_Sequence MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSGSPEGVVKAGAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQEPPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAAEGFFRDRSGKF
Organism_Source Homo sapiens
Functional_Classification chromodomain-containing proteins
Cellular_Localization Nucleus
Gene_Names CBX7
UniProt_ID O95931
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name H3K27me3
Peptide_Sequence QLATKAARXSAPATG
Peptide_Length 15
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification X9=trimethyllysine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Fluorescein
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1399.57
Aliphatic_Index 59.33333
Aromaticity 0.00000
Average_Rotatable_Bonds 2.93333
Charge_at_pH_7 1.99769
Isoelectric_Point 11.65178
Number_of_Hydrogen_Bond_Acceptors 22
Number_of_Hydrogen_Bond_Donors 23
Topological_Polar_Surface_Area 653.63000
X_logP_energy -10.48823
Interaction Information
Affinity KD=140 uM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Recognition and specificity determinants of the human cbx chromodomains.
Release_Year 2011
PMID 21047797
DOI 10.1074/jbc.M110.191411