PPIRE12190

Target Protein Information
Protein_Name Telomeric repeat-binding factor 1
Protein_Sequence MAEDVSSAAPSPRGCADGRDADPTEEQMAETERNDEEQFECQELLECQVQVGAPEEEEEEEEDAGLVAEAEAVAAGWMLDFLCLSLCRAFRDGRSEDFRRTRNSAEAIIHGLSSLTACQLRTIYICQFLTRIAAGKTLDAQFENDERITPLESALMIWGSIEKEHDKLHEEIQNLIKIQAIAVCMENGNFKEAEEVFERIFGDPNSHMPFKSKLLMIISQKDTFHSFFQHFSYNHMMEKIKSYVNYVLSEKSSTFLMKAAAKVVESKRTRTITSQDKPSGNDVEMETEANLDTRKSVSDKQSAVTESSEGTVSLLRSHKNLFLSKLQHGTQQQDLNKKERRVGTPQSTKKKKESRRATESRIPVSKSQPVTPEKHRARKRQAWLWEEDKNLRSGVRKYGEGNWSKILLHYKFNNRTSVMLKDRWRTMKKLKLISSDSED
Organism_Source Homo sapiens
Functional_Classification shelterin subunit
Cellular_Localization Nucleus
Gene_Names TERF1
UniProt_ID P54274
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name TERB1TBM
Peptide_Sequence EGAILLTPRRRQVQG
Peptide_Length 15
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)O)C(C)C)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1693.97
Aliphatic_Index 104.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.80000
Charge_at_pH_7 1.99975
Isoelectric_Point 12.19913
Number_of_Hydrogen_Bond_Acceptors 23
Number_of_Hydrogen_Bond_Donors 28
Topological_Polar_Surface_Area 791.34000
X_logP_energy -8.66489
Interaction Information
Affinity KD=5.6 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 5XUP
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Telomeric TERB1-TRF1 interaction is crucial for male meiosis.
Release_Year 2017
PMID 29083416
DOI 10.1038/nsmb.3496