PPIRE12194

Target Protein Information
Protein_Name WD repeat-containing protein 5
Protein_Sequence MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
Organism_Source Homo sapiens
Functional_Classification WD40 domain-containing proteins
Cellular_Localization Nucleus
Gene_Names WDR5
UniProt_ID P61964
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name NS1Rme0
Peptide_Sequence PKQKRKMARTARSKV
Peptide_Length 15
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)O)C(C)C)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1785.19
Aliphatic_Index 32.66667
Aromaticity 0.00000
Average_Rotatable_Bonds 4.40000
Charge_at_pH_7 6.99679
Isoelectric_Point 12.82564
Number_of_Hydrogen_Bond_Acceptors 27
Number_of_Hydrogen_Bond_Donors 32
Topological_Polar_Surface_Area 830.06000
X_logP_energy -9.99649
Interaction Information
Affinity KD=70 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 4O45
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1.
Release_Year 2014
PMID 24853335
DOI 10.1038/ncomms4952