PPIRE12203

Target Protein Information
Protein_Name Protein salvador homolog 1
Protein_Sequence MLSRKKTKNEVSKPAEVQGKYVKKETSPLLRNLMPSFIRHGPTIPRRTDICLPDSSPNAFSTSGDVVSRNQSFLRTPIQRTPHEIMRRESNRLSAPSYLARSLADVPREYGSSQSFVTEVSFAVENGDSGSRYYYSDNFFDGQRKRPLGDRAHEDYRYYEYNHDLFQRMPQNQGRHASGIGRVAATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTYQPQQTERNQSLLVPANPYHTAEIPDWLQVYARAPVKYDHILKWELFQLADLDTYQGMLKLLFMKELEQIVKMYEAYRQALLTELENRKQRQQWYAQQHGKNF
Organism_Source Homo sapiens
Functional_Classification Hippo pathway scaffold
Cellular_Localization Cytoplasm
Gene_Names SAV1
UniProt_ID Q9H4B6
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Lats1-PPXY
Peptide_Sequence AGTVNRQPPPYPNGQS
Peptide_Length 16
Peptide_SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1682.81
Aliphatic_Index 24.37500
Aromaticity 0.06250
Average_Rotatable_Bonds 2.87500
Charge_at_pH_7 0.99713
Isoelectric_Point 9.34881
Number_of_Hydrogen_Bond_Acceptors 25
Number_of_Hydrogen_Bond_Donors 23
Topological_Polar_Surface_Area 759.61000
X_logP_energy -11.49973
Interaction Information
Affinity KD=156 uM
Affinity_Assay not reported
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling.
Release_Year 2015
PMID 26108669
DOI 10.1101/gad.264929.115