PPIRE12213

Target Protein Information
Protein_Name Major prion protein
Protein_Sequence MANLGYWLLALFVTMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGTWGQPHGGGWGQPHGGSWGQPHGGSWGQPHGGGWGQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSSTVLFSSPPVILLISFLIFLIVG
Organism_Source Mus musculus
Functional_Classification GPI-anchored proteins
Cellular_Localization Plasma membrane
Gene_Names Prnp
UniProt_ID P04925
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide aptamer 8
Peptide_Sequence ARFEYLRDGYWVWRFT
Peptide_Length 16
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)O)[C@@H](C)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2165.44
Aliphatic_Index 48.75000
Aromaticity 0.37500
Average_Rotatable_Bonds 4.00000
Charge_at_pH_7 0.99850
Isoelectric_Point 9.17050
Number_of_Hydrogen_Bond_Acceptors 25
Number_of_Hydrogen_Bond_Donors 33
Topological_Polar_Surface_Area 852.39000
X_logP_energy -2.63619
Interaction Information
Affinity IC50=700 nM
Affinity_Assay PK digestion immunoblot assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Peptide aptamers expressed in the secretory pathway interfere with cellular PrPSc formation.
Release_Year 2007
PMID 17574575
DOI 10.1016/j.jmb.2007.05.052