PPIRE12221

Target Protein Information
Protein_Name Zinc finger CW-type PWWP domain protein 2
Protein_Sequence MDKEKLDVKIEYCNYAMDSSVENMYVNKVWVQCENENCLKWRLLSSEDSAKVDHDEPWYCFMNTDSRYNNCSISEEDFPEESQLHQCGFKIVYSQLPLGSLVLVKLQNWPSWPGILCPDRFKGKYVTYDPDGNVEEYHIEFLGDPHSRSWIKATFVGHYSITLKPEKCKNKKKWYKSALQEACLLYGYSHEQRLEMCCLSKLQDKSETHDKVAALVKKRKQTSKNNIEKKKPKFRKRKRKAILKCSFENVYSDDALSKENRVVCETEVLLKELEQMLQQALQPTATPDESEEGHGEEINMGEKLSKCSPEAPAGSLFENHYEEDYLVIDGIKLKAGECIEDITNKFKEIDALMSEF
Organism_Source Homo sapiens
Functional_Classification histone modification reader
Cellular_Localization Nucleus
Gene_Names ZCWPW2
UniProt_ID Q504Y3
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name H3R2me2sK4me3
Peptide_Sequence ARTKQTARKSTGGKAP
Peptide_Length 16
Peptide_SMILES C[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification R2=symmetric dimethylarginine; K4=trimethyllysine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1657.89
Aliphatic_Index 18.75000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.56250
Charge_at_pH_7 4.99709
Isoelectric_Point 12.54608
Number_of_Hydrogen_Bond_Acceptors 27
Number_of_Hydrogen_Bond_Donors 30
Topological_Polar_Surface_Area 816.90000
X_logP_energy -13.18726
Interaction Information
Affinity KD=11.9 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 4O62
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Family-wide Characterization of Histone Binding Abilities of Human CW Domain-containing Proteins.
Release_Year 2016
PMID 26933034
DOI 10.1074/jbc.M116.718973