PPIRE12232

Target Protein Information
Protein_Name Histone H3.1
Protein_Sequence MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
Organism_Source Homo sapiens
Functional_Classification histones
Cellular_Localization Nucleus
Gene_Names H3C1
UniProt_ID P68431
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name H3K4me3 peptide
Peptide_Sequence ARTKQTARKSTGGYCD
Peptide_Length 16
Peptide_SMILES C[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)O)C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1742.93
Aliphatic_Index 12.50000
Aromaticity 0.06250
Average_Rotatable_Bonds 3.68750
Charge_at_pH_7 2.93501
Isoelectric_Point 10.25201
Number_of_Hydrogen_Bond_Acceptors 29
Number_of_Hydrogen_Bond_Donors 33
Topological_Polar_Surface_Area 857.20000
X_logP_energy -13.48956
Interaction Information
Affinity KD=0.21 nM
Affinity_Assay peptide immunoprecipitation assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Broad ranges of affinity and specificity of anti-histone antibodies revealed by a quantitative peptide immunoprecipitation assay.
Release_Year 2012
PMID 23041298
DOI 10.1016/j.jmb.2012.09.022