PPIRE12240

Target Protein Information
Protein_Name Major prion protein
Protein_Sequence MANLGYWLLALFVTMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGTWGQPHGGGWGQPHGGSWGQPHGGSWGQPHGGGWGQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSSTVLFSSPPVILLISFLIFLIVG
Organism_Source Mus musculus
Functional_Classification GPI-anchored proteins
Cellular_Localization Plasma membrane
Gene_Names Prnp
UniProt_ID P04925
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide aptamer 16
Peptide_Sequence CGRWAIRTVHIWLACG
Peptide_Length 16
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@@H](N)CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1842.21
Aliphatic_Index 103.75000
Aromaticity 0.12500
Average_Rotatable_Bonds 3.43750
Charge_at_pH_7 1.96494
Isoelectric_Point 8.83790
Number_of_Hydrogen_Bond_Acceptors 23
Number_of_Hydrogen_Bond_Donors 29
Topological_Polar_Surface_Area 704.11000
X_logP_energy -4.05206
Interaction Information
Affinity IC50=350 nM
Affinity_Assay PK digestion immunoblot assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Peptide aptamers expressed in the secretory pathway interfere with cellular PrPSc formation.
Release_Year 2007
PMID 17574575
DOI 10.1016/j.jmb.2007.05.052