PPIRE12243
Target Protein Information
| Protein_Name | Dual endothelin-1/VEGF signal peptide receptor |
|---|---|
| Protein_Sequence | MTMFKGSNEMKSRWNWGSITCIICFTCVGSQLSMSSSKASNFSGPLQLYQRELEIFIVLTDVPNYRLIKENSHLHTTIVDQGRTV |
| Organism_Source | Homo sapiens |
| Functional_Classification | E3 ubiquitin ligases |
| Cellular_Localization | Nucleus |
| Gene_Names | FBXW7-AS1 |
| UniProt_ID | B0L3A2 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | DISC1193-207 phosphodegron peptide |
|---|---|
| Peptide_Sequence | CPERPTPPPGSHTVFC |
| Peptide_Length | 16 |
| Peptide_SMILES | CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CS)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)O |
| Chemical_Modification | T6=phosphorylation; S10=phosphorylation |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1724.97 |
|---|---|
| Aliphatic_Index | 18.12500 |
| Aromaticity | 0.06250 |
| Average_Rotatable_Bonds | 2.68750 |
| Charge_at_pH_7 | -0.03328 |
| Isoelectric_Point | 7.25427 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 25 |
| Number_of_Hydrogen_Bond_Donors | 22 |
| Topological_Polar_Surface_Area | 644.44000 |
| X_logP_energy | -7.56123 |
Interaction Information
| Affinity | KD=1 uM |
|---|---|
| Affinity_Assay | Isothermal titration calorimetry |
| PDB_ID | 5V4B |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system. |
| Release_Year | 2017 |
| PMID | 28727686 |
| DOI | 10.1038/mp.2017.138 |