PPIRE12250

Target Protein Information
Protein_Name Metallothionein-3
Protein_Sequence MDPETCPCPSGGSCTCADSCKCEGCKCTSCKKSCCSCCPAECEKCAKDCVCKGGEAAEAEAEKCSCCQ
Organism_Source Homo sapiens
Functional_Classification metal-binding proteins
Cellular_Localization Extracellular
Gene_Names MT3
UniProt_ID P25713
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Abeta1-16(Y10A)
Peptide_Sequence DAEFRHDSGAEVHHQK
Peptide_Length 16
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1862.94
Aliphatic_Index 30.62500
Aromaticity 0.06250
Average_Rotatable_Bonds 3.87500
Charge_at_pH_7 -1.72514
Isoelectric_Point 6.21402
Number_of_Hydrogen_Bond_Acceptors 28
Number_of_Hydrogen_Bond_Donors 30
Topological_Polar_Surface_Area 886.30000
X_logP_energy -10.53333
Interaction Information
Affinity KD=83 uM
Affinity_Assay Surface plasmon resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Metal-dependent interactions of metallothionein-3 Beta-domain with amyloid-Beta peptide and related physiological implications.
Release_Year 2019
PMID 31005822
DOI 10.1016/j.jinorgbio.2019.110693