PPIRE12258

Target Protein Information
Protein_Name Protein Mdm4
Protein_Sequence MTSLASSSQLPGSCRTLPGEGTQVHPRAPLLQILKVAGAQEEVFTLKEVMHYLGQYIMMKQLYDKQRQHIVHCHDDPLGELLEVGSFSVKNPSPVYEMLKRNLVILNNSDAAKNLSVGKDSNESPSEDPGQVSSGSINSAQPLIAGSSSTGTTQSCSQRRPRDPDEDSSDGLPRSACKRPKLDVTLEEWDLSGLPWWFLGNLRSNYTRRSNGSTDIHTNQLSPGQDEDTAIVSDTTDDLWFLNEAESEQVSVEIKEAVLEQGSDGESPHEDEDTGKDSKDDGKMQEEQEEDSQCLSDDTDTEISTQDAWQCSECRKFNTPLQRYCMRCWALRKDWYKDCPRLVHSISVPDIPACSSRPERDEDEEEEDDDGIDMPDCLRTVSDPVVLPSHRVSRNIPSSSASSSKGKGPSQIHHHFQETSEGDSQDTLDMETEYQPEALLEPCKLCRVRPRNGNIIHGRTAHLITCFPCARKLHKFHAPCPGCGQVIQKVIKTFIA
Organism_Source Danio rerio
Functional_Classification ubiquitin ligases
Cellular_Localization Nucleus
Gene_Names mdm4
UniProt_ID Q7ZUW7
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Zebrafish p53 peptide Z
Peptide_Sequence DSQEFAELWEKNLIIQ
Peptide_Length 16
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)O)[C@@H](C)CC
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1963.17
Aliphatic_Index 103.75000
Aromaticity 0.12500
Average_Rotatable_Bonds 4.18750
Charge_at_pH_7 -2.99654
Isoelectric_Point 3.77824
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 27
Topological_Polar_Surface_Area 840.33000
X_logP_energy -5.56190
Interaction Information
Affinity KD=0.21 mM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 2Z5S
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Molecular basis for the inhibition of p53 by Mdmx.
Release_Year 2007
PMID 17938582
DOI 10.4161/cc.6.19.4740