PPIRE12286

Target Protein Information
Protein_Name Microtubule-associated protein 1 light chain 3 beta
Protein_Sequence MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
Organism_Source Homo sapiens
Functional_Classification autophagy modifiers
Cellular_Localization Cytoplasm
Gene_Names MAP1LC3B
UniProt_ID Q9GZQ8
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name UBA5 LIR(333-348)
Peptide_Sequence EIIHEDNEWGIELVSE
Peptide_Length 16
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CCC(=O)O)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1912.04
Aliphatic_Index 115.62500
Aromaticity 0.06250
Average_Rotatable_Bonds 4.00000
Charge_at_pH_7 -5.90178
Isoelectric_Point 3.58854
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 27
Topological_Polar_Surface_Area 831.41000
X_logP_energy -5.50170
Interaction Information
Affinity KD=2.3 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5)interacts with GABARAP proteins and mediates membrane localization of UBA5.
Release_Year 2019
PMID 30990354
DOI 10.1080/15548627.2019.1606637