PPIRE12303

Target Protein Information
Protein_Name Calmodulin-1
Protein_Sequence MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
Organism_Source Homo sapiens
Functional_Classification EF-hand calcium-binding protein
Cellular_Localization Cytoplasm
Gene_Names CALM1
UniProt_ID P0DP23
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name AKAP79 16-mer
Peptide_Sequence GAWASLKRLVTRRKRS
Peptide_Length 16
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)CN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1885.25
Aliphatic_Index 79.37500
Aromaticity 0.06250
Average_Rotatable_Bonds 4.06250
Charge_at_pH_7 5.99738
Isoelectric_Point 12.98470
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 35
Topological_Polar_Surface_Area 875.94000
X_logP_energy -9.50982
Interaction Information
Affinity Ki=75 nM
Affinity_Assay ELISA
PDB_ID 5NIN
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Molecular basis of AKAP79 regulation by calmodulin.
Release_Year 2017
PMID 29162807
DOI 10.1038/s41467-017-01715-w