PPIRE12342

Target Protein Information
Protein_Name WD repeat-containing protein 5
Protein_Sequence MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
Organism_Source Homo sapiens
Functional_Classification WD repeat proteins
Cellular_Localization Nucleus
Gene_Names WDR5
UniProt_ID P61964
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SETd1a Win motif peptide
Peptide_Sequence HNSMKPESRACGTPNV
Peptide_Length 16
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)O)C(C)C)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1727.93
Aliphatic_Index 24.37500
Aromaticity 0.00000
Average_Rotatable_Bonds 3.37500
Charge_at_pH_7 1.02840
Isoelectric_Point 8.55269
Number_of_Hydrogen_Bond_Acceptors 28
Number_of_Hydrogen_Bond_Donors 27
Topological_Polar_Surface_Area 783.01000
X_logP_energy -11.98803
Interaction Information
Affinity KD=541 nM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 4EWR
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structural basis for WDR5 interaction (Win)motif recognition in human SET1 family histone methyltransferases.
Release_Year 2012
PMID 22665483
DOI 10.1074/jbc.M112.364125