PPIRE12346

Target Protein Information
Protein_Name Neuropeptide Y receptor type 1
Protein_Sequence MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names NPY1R
UniProt_ID P25929
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name INP-K[e-J-(a-DO3A-e-DGa)-K]YRLRY-NH2
Peptide_Sequence INPKXXaDXKYRLRY
Peptide_Length 15
Peptide_SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O
Chemical_Modification X5=DO3A-e-DGa; J5=4-aminophenylalanine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1765.00
Aliphatic_Index 55.00000
Aromaticity 0.12500
Average_Rotatable_Bonds 3.62500
Charge_at_pH_7 2.99613
Isoelectric_Point 10.44817
Number_of_Hydrogen_Bond_Acceptors 25
Number_of_Hydrogen_Bond_Donors 28
Topological_Polar_Surface_Area 787.72000
X_logP_energy -8.15456
Interaction Information
Affinity IC50=80 nM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title In Vitro Mouse and Human Serum Stability of a Heterobivalent Dual-Target Probe That Has Strong Affinity to Gastrin-Releasing Peptide and Neuropeptide Y1 Receptors on Tumor Cells.
Release_Year 2017
PMID 28186846
DOI 10.1089/cbr.2016.2136