PPIRE12366

Target Protein Information
Protein_Name Apoptosis regulator Bcl-2 homolog
Protein_Sequence MDPSVKKDEIYYTILNIIQNYFIEYCTGKNRNFHVEDENTYIIVKNMCDIILRDNIVEFRKDIDRCSDIENEIPEIVYDTIHDKITWGRVISIIAFGAYVTKVFKEKGRDNVVDLMPDIITESLLSRCRSWLSDQNCWDGLKAYVYNNKKFYYVTRYFRVAAFIITSLAVINLFL
Organism_Source Canarypox virus
Functional_Classification Bcl-2-like proteins
Cellular_Localization Mitochondrion
Gene_Names CNPV058
UniProt_ID Q6VZT9
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name HS_Hrk
Peptide_Sequence RSSAAQLTAARLKAIGDELHQRTMWR
Peptide_Length 26
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCCNC(=N)N)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2967.40
Aliphatic_Index 79.23077
Aromaticity 0.03846
Average_Rotatable_Bonds 3.88462
Charge_at_pH_7 3.09081
Isoelectric_Point 12.05318
Number_of_Hydrogen_Bond_Acceptors 42
Number_of_Hydrogen_Bond_Donors 50
Topological_Polar_Surface_Area 1350.61000
X_logP_energy -15.32472
Interaction Information
Affinity KD=312 nM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structural and Functional Insight into Canarypox Virus CNP058 Mediated Regulation of Apoptosis.
Release_Year 2017
PMID 29053589
DOI 10.3390/v9100305