PPIRE12389

Target Protein Information
Protein_Name Apoptosis regulator Bcl-2 homolog
Protein_Sequence MDPSVKKDEIYYTILNIIQNYFIEYCTGKNRNFHVEDENTYIIVKNMCDIILRDNIVEFRKDIDRCSDIENEIPEIVYDTIHDKITWGRVISIIAFGAYVTKVFKEKGRDNVVDLMPDIITESLLSRCRSWLSDQNCWDGLKAYVYNNKKFYYVTRYFRVAAFIITSLAVINLFL
Organism_Source Canarypox virus
Functional_Classification Bcl-2-like proteins
Cellular_Localization Mitochondrion
Gene_Names CNPV058
UniProt_ID Q6VZT9
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name GG_Bid
Peptide_Sequence PEVNEAIVRTIAAQLAEIGDQLDKQIKAKVVNDL
Peptide_Length 34
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3703.25
Aliphatic_Index 129.11765
Aromaticity 0.00000
Average_Rotatable_Bonds 3.82353
Charge_at_pH_7 -1.99624
Isoelectric_Point 4.35510
Number_of_Hydrogen_Bond_Acceptors 51
Number_of_Hydrogen_Bond_Donors 53
Topological_Polar_Surface_Area 1609.07000
X_logP_energy -14.90413
Interaction Information
Affinity KD=50 nM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structural and Functional Insight into Canarypox Virus CNP058 Mediated Regulation of Apoptosis.
Release_Year 2017
PMID 29053589
DOI 10.3390/v9100305