PPIRE12406

Target Protein Information
Protein_Name Regulator of Ty1 transposition protein 103
Protein_Sequence MPFSSEQFTTKLNTLEDSQESISSASKWLLLQYRDAPKVAEMWKEYMLRPSVNTRRKLLGLYLMNHVVQQAKGQKIIQFQDSFGKVAAEVLGRINQEFPRDLKKKLSRVVNILKERNIFSKQVVNDIERSLKTESSPVEALVLPQKLKDFAKDYEKLVKMHHNVCAMKMRFDKSSDELDPSSSVYEENFKTISKIGNMAKDIINESILKRESGIHKLQSTLDDEKRHLDEEQNMLSEIEFVLSAKDPSRLNKNVDEDNIIPTYEVGDGDDDDDDGDNDDDDDDDDDDKNYDDRSNDSNYGVTNISTTDKKNEVVEKTDSEHKNSTHNPSDNQFGMKRTHDMIGHDDANDIPEKKVHLDSKTSEDGTFNSEDGHYELDIEGHVGAQTDEGVENSGGVSSSIQDLLSKLAN
Organism_Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Functional_Classification transcription termination factors
Cellular_Localization Nucleus
Gene_Names RTT103
UniProt_ID Q05543
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name pThr4-CTD
Peptide_Sequence PSYSPTSPSYSPTSPS
Peptide_Length 16
Peptide_SMILES C[C@@H](O)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification T6=phosphothreonine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification 5,6-Carboxyfluorescein
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1641.71
Aliphatic_Index 0.00000
Aromaticity 0.12500
Average_Rotatable_Bonds 2.50000
Charge_at_pH_7 -0.00372
Isoelectric_Point 6.08660
Number_of_Hydrogen_Bond_Acceptors 28
Number_of_Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 673.20000
X_logP_energy -12.27590
Interaction Information
Affinity KD=15 uM
Affinity_Assay fluorescence anisotropy
PDB_ID 5LVF
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural insight into recognition of phosphorylated threonine-4 of RNA polymerase II C-terminal domain by Rtt103p.
Release_Year 2017
PMID 28468956
DOI 10.15252/embr.201643723