PPIRE12413

Target Protein Information
Protein_Name Genome polyprotein
Protein_Sequence TTQGCNCSIYPGHITGHRMAWDMMMNWSPTTALVVAQLLRIPQAILDMIAGAHWGVLAGIAYFSMVGNWAKVLAVLLLFAGVDAETHVTGGIAAKTTASLTGLFNLGAKQNIQLINTNGSWHINRTALNCNDSLNTGW
Organism_Source Hepatitis C virus (isolate EC10)
Functional_Classification viral glycoproteins
Cellular_Localization Extracellular
Gene_Names None
UniProt_ID P27953
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name E2_412-423_peptide
Peptide_Sequence QLINTNGSWHINGSGK
Peptide_Length 16
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)CC)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification biotin
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1725.88
Aliphatic_Index 73.12500
Aromaticity 0.06250
Average_Rotatable_Bonds 3.56250
Charge_at_pH_7 1.08860
Isoelectric_Point 9.70200
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 27
Topological_Polar_Surface_Area 803.36000
X_logP_energy -11.22130
Interaction Information
Affinity KD=12 nM
Affinity_Assay Bio-Layer Interferometry
PDB_ID 4HS8
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Glycan shifting on hepatitis C virus (HCV)E2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies.
Release_Year 2013
PMID 23458406
DOI 10.1016/j.jmb.2013.02.025