PPIRE12428
Target Protein Information
| Protein_Name | Small ubiquitin-related modifier 2 |
|---|---|
| Protein_Sequence | MADEKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVY |
| Organism_Source | Homo sapiens |
| Functional_Classification | SUMO proteins |
| Cellular_Localization | Nucleus |
| Gene_Names | SUMO2 |
| UniProt_ID | P61956 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | RAP80-(35-50) |
|---|---|
| Peptide_Sequence | RLEDAFIVISDSDGEE |
| Peptide_Length | 16 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)[C@@H](C)CC)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Acetyl |
| C-terminal_Modification | amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1794.89 |
|---|---|
| Aliphatic_Index | 97.50000 |
| Aromaticity | 0.06250 |
| Average_Rotatable_Bonds | 3.81250 |
| Charge_at_pH_7 | -4.99535 |
| Isoelectric_Point | 3.53218 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 26 |
| Number_of_Hydrogen_Bond_Donors | 28 |
| Topological_Polar_Surface_Area | 825.98000 |
| X_logP_energy | -8.37503 |
Interaction Information
| Affinity | KD=239 uM |
|---|---|
| Affinity_Assay | NMR chemical shift perturbation |
| PDB_ID | 2N9E |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Molecular Basis for Phosphorylation-dependent SUMO Recognition by the DNA Repair Protein RAP80. |
| Release_Year | 2016 |
| PMID | 26719330 |
| DOI | 10.1074/jbc.M115.705061 |