PPIRE12430

Target Protein Information
Protein_Name Insulin-like growth factor 1
Protein_Sequence MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARSVRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGWPKTHPGGEQKEGTEASLQIRGKKKEQRREIGSRNAECRGKKGK
Organism_Source Homo sapiens
Functional_Classification growth factors
Cellular_Localization Extracellular
Gene_Names IGF1
UniProt_ID P05019
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name IGF-F1-1
Peptide_Sequence RNCFESVAALRRCMYG
Peptide_Length 16
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1876.20
Aliphatic_Index 55.00000
Aromaticity 0.12500
Average_Rotatable_Bonds 3.81250
Charge_at_pH_7 1.87495
Isoelectric_Point 8.80375
Number_of_Hydrogen_Bond_Acceptors 27
Number_of_Hydrogen_Bond_Donors 32
Topological_Polar_Surface_Area 806.37000
X_logP_energy -8.63039
Interaction Information
Affinity IC50=7.2 uM
Affinity_Assay ELISA
PDB_ID 1PMX
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Complex with a phage display-derived peptide provides insight into the function of insulin-like growth factor I.
Release_Year 2003
PMID 12899619
DOI 10.1021/bi034386c