PPIRE12446

Target Protein Information
Protein_Name Uncharacterized protein encoded by SND1-IT1
Protein_Sequence MSHHPHSLRNSCLIRMDLLYWQFTIYTITFCFSHLSGRLTLSAQHISHRPCLLSYSLLFWKVHHLFLEGFPCSPRLDEMSFHQFPQHPVHVSVVHLPIVYKGSMTQVSPH
Organism_Source Homo sapiens
Functional_Classification Tudor domain-containing proteins
Cellular_Localization Cytoplasm
Gene_Names SND1-IT1
UniProt_ID Q9HBX3
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name PIWIL1 R4me2s peptide
Peptide_Sequence TGRARARARGRARGQE
Peptide_Length 16
Peptide_SMILES C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O
Chemical_Modification R3=symmetrical dimethylarginine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1768.96
Aliphatic_Index 25.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.87500
Charge_at_pH_7 4.99974
Isoelectric_Point 12.80105
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 38
Topological_Polar_Surface_Area 971.84000
X_logP_energy -15.26518
Interaction Information
Affinity KD=10 uM
Affinity_Assay Fluorescence Polarization
PDB_ID 3OMG
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain.
Release_Year 2010
PMID 20937909
DOI 10.1073/pnas.1013106107