PPIRE12452

Target Protein Information
Protein_Name Importin subunit alpha
Protein_Sequence MADRYIPEHRRTQFKAKSAFKPDELRRRREEQQVEIRKAKREENLAKRRGIGAGDSRPGASLGAAPDSDDENPPTESQLSEDLPKMVEGVFSSEIDKQIQATTKFRKLLSKERNPPIEEVIKTGVVGRFVEFLRSPHTLVQFEAAWALTNIASGSATQTQVVIEAGAVPIFVELLGSPEPDVREQAVWALGNIAGDSPQCRDYVLSCGALRPLLTLLGDSRKLSMLRNATWTLSNFCRGKTPQPDWNTIAPALPVLAKLVYSLDDEVLIDACWAISYLSDGSNDKIQAVIEAGIPRRLVELLMHASTSVQTPALRSVGNIVTGDDVQTQVIINCGALPCLLSLLSSNKDGIRKEACWTISNITAGNSAQIQSVIDANIIPPLIHLLSHADLKTRKEACWAISNATSGGLQKPDQIRYLVAQGCIKPLCDLLACPDNKIIQVALDGLENILKVGELDKNAAGDGPDSINRYALFIEECGGMEKIHDCQTNANEEIYMKAYNIIEKYFSDEDEAGDEAMGAQQQFGFGASGGAQQGGFNFGANGTESMDM
Organism_Source Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Functional_Classification nuclear transport receptors
Cellular_Localization Cytoplasm
Gene_Names None
UniProt_ID Q1K6K3
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name NIT-2 NLS
Peptide_Sequence TISSKRQRRHSKS
Peptide_Length 13
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1570.78
Aliphatic_Index 30.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 4.38462
Charge_at_pH_7 5.08829
Isoelectric_Point 12.81364
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 32
Topological_Polar_Surface_Area 823.18000
X_logP_energy -13.10889
Interaction Information
Affinity KD=9.9 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 5VQI
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Nuclear transport of the Neurospora crassa NIT-2 transcription factor is mediated by importin-Alpha.
Release_Year 2017
PMID 29054975
DOI 10.1042/BCJ20170654