PPIRE12459

Target Protein Information
Protein_Name Vacuolar protein sorting-associated protein 4A
Protein_Sequence MTTSTLQKAIDLVTKATEEDKAKNYEEALRLYQHAVEYFLHAIKYEAHSDKAKESIRAKCVQYLDRAEKLKDYLRSKEKHGKKPVKENQSEGKGSDSDSEGDNPEKKKLQEQLMGAVVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQSATHFKKVCGPSRTNPSMMIDDLLTPCSPGDPGAMEMTWMDVPGDKLLEPVVCMSDMLRSLATTRPTVNADDLLKVKKFSEDFGQES
Organism_Source Homo sapiens
Functional_Classification ATPases
Cellular_Localization Cytoplasm
Gene_Names VPS4A
UniProt_ID Q9UN37
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name CHMP1A180-196
Peptide_Sequence VRSQEDQLDEEILEAM
Peptide_Length 16
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1905.06
Aliphatic_Index 97.50000
Aromaticity 0.00000
Average_Rotatable_Bonds 4.25000
Charge_at_pH_7 -4.99403
Isoelectric_Point 3.56007
Number_of_Hydrogen_Bond_Acceptors 28
Number_of_Hydrogen_Bond_Donors 29
Topological_Polar_Surface_Area 891.93000
X_logP_energy -8.56723
Interaction Information
Affinity KD=4.61 mM
Affinity_Assay Bio-Layer Interferometry
PDB_ID 2JQ9
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title ESCRT-III recognition by VPS4 ATPases.
Release_Year 2007
PMID 17928862
DOI 10.1038/nature06172