PPIRE12463

Target Protein Information
Protein_Name Genome polyprotein
Protein_Sequence TTQGCNCSIYPGHITGHRMAWDMMMNWSPTTALVVAQLLRIPQAILDMIAGAHWGVLAGIAYFSMVGNWAKVLAVLLLFAGVDAETHVTGGIAAKTTASLTGLFNLGAKQNIQLINTNGSWHINRTALNCNDSLNTGW
Organism_Source Hepatitis C virus (isolate EC10)
Functional_Classification envelope glycoproteins
Cellular_Localization Extracellular
Gene_Names None
UniProt_ID P27953
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide 75
Peptide_Sequence VSFAIKWEYVLLLFLL
Peptide_Length 16
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1954.43
Aliphatic_Index 188.75000
Aromaticity 0.25000
Average_Rotatable_Bonds 3.81250
Charge_at_pH_7 -0.00139
Isoelectric_Point 6.40200
Number_of_Hydrogen_Bond_Acceptors 21
Number_of_Hydrogen_Bond_Donors 22
Topological_Polar_Surface_Area 619.39000
X_logP_energy 3.42260
Interaction Information
Affinity IC50=0.3 uM
Affinity_Assay luciferase reporter assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title A peptide derived from hepatitis C virus E2 envelope protein inhibits a post-binding step in HCV entry.
Release_Year 2010
PMID 20156485
DOI 10.1016/j.antiviral.2010.02.316