PPIRE12473

Target Protein Information
Protein_Name Immunoglobulin heavy constant gamma 2B
Protein_Sequence KTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKLEPSGPISTINPCPPCKECHKCPAPNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIKGLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSPGLDLDDICAEAKDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVELKQKISPDYRNMIGQGA
Organism_Source Mus musculus
Functional_Classification immunoglobulin
Cellular_Localization Extracellular
Gene_Names Ighg2b
UniProt_ID P01867
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name AbetapE3-18
Peptide_Sequence XFRHDSGYEVHHQKLV
Peptide_Length 16
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)CN)C(C)C)C(=O)N[C@H](C(=O)O)C(C)C
Chemical_Modification X1=pyroglutamate
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Pyroglutamate
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1909.09
Aliphatic_Index 60.62500
Aromaticity 0.12500
Average_Rotatable_Bonds 3.87500
Charge_at_pH_7 0.27178
Isoelectric_Point 7.80126
Number_of_Hydrogen_Bond_Acceptors 27
Number_of_Hydrogen_Bond_Donors 29
Topological_Polar_Surface_Area 831.93000
X_logP_energy -7.63083
Interaction Information
Affinity KD=0.99 nM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 5MY4
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural and functional analyses of pyroglutamate-amyloid-Beta-specific antibodies as a basis for Alzheimer immunotherapy.
Release_Year 2017
PMID 28623233
DOI 10.1074/jbc.M117.777839