PPIRE12501
Target Protein Information
| Protein_Name | Neuronal acetylcholine receptor subunit alpha-6 |
|---|---|
| Protein_Sequence | MLNGWGRGDLRSGLCLWICGFLAFFKGSRGCVSEEQLFHTLFAHYNRFIRPVENVSDPVTVHFELAITQLANVDEVNQIMETNLWLRHVWKDYRLCWDPTEYDGIETLRVPADNIWKPDIVLYNNAVGDFQVEGKTKALLKYDGVITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIVDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPATHTMPKWVKTMFLQVFPSILMMRRPLDKTKEMDGVKDPKTHTKRPAKVKFTHRKEPKLLKECRHCHKSSEIAPGKRLSQQPAQWVTENSEHPPDVEDVIDSVQFIAENMKSHNETKEVEDDWKYMAMVVDRVFLWVFIIVCVFGTVGLFLQPLLGNTGAS |
| Organism_Source | Rattus norvegicus |
| Functional_Classification | ligand-gated ion channels |
| Cellular_Localization | Plasma membrane |
| Gene_Names | Chrna6 |
| UniProt_ID | P43143 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | alpha-Conotoxin TxIB |
|---|---|
| Peptide_Sequence | GCCSDPPCRNKHPDLC |
| Peptide_Length | 16 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CS)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)CN)C(=O)N[C@@H](CS)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | Side chain cyclization; C2<->C8; disulfide bond; C3<->C16; disulfide bond |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1744.99 |
|---|---|
| Aliphatic_Index | 24.37500 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.18750 |
| Charge_at_pH_7 | -0.15841 |
| Isoelectric_Point | 7.12334 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 28 |
| Number_of_Hydrogen_Bond_Donors | 27 |
| Topological_Polar_Surface_Area | 727.97000 |
| X_logP_energy | -10.23923 |
Interaction Information
| Affinity | IC50=28 nM |
|---|---|
| Affinity_Assay | two-electrode voltage clamp electrophysiology |
| PDB_ID | None |
| Type | Ion channel modulator |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Alpha-Conotoxin TxIB: A Uniquely Selective Ligand for Alpha6/Alpha3Beta2Beta3 Nicotinic Acetylcholine Receptor Attenuates Nicotine-Induced Conditioned Place Preference in Mice. |
| Release_Year | 2019 |
| PMID | 31443523 |
| DOI | 10.3390/md17090490 |