PPIRE12531

Target Protein Information
Protein_Name Transcriptional enhancer factor TEF-1
Protein_Sequence MEPSSWSGSESPAENMERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSRDFHSKLKDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGAPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQDDAGAFYGVTSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD
Organism_Source Homo sapiens
Functional_Classification TEA domain transcription factor
Cellular_Localization Nucleus
Gene_Names TEAD1
UniProt_ID P28347
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide 8
Peptide_Sequence VPMXLRKXPSFCKPPE
Peptide_Length 16
Peptide_SMILES CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)O
Chemical_Modification X4=homocysteine; X8=norleucine
Cyclization_Method side chain-side chain cyclization; X4<->C13; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1743.12
Aliphatic_Index 42.50000
Aromaticity 0.06250
Average_Rotatable_Bonds 3.25000
Charge_at_pH_7 1.93719
Isoelectric_Point 9.67375
Number_of_Hydrogen_Bond_Acceptors 24
Number_of_Hydrogen_Bond_Donors 21
Topological_Polar_Surface_Area 636.13000
X_logP_energy -5.03603
Interaction Information
Affinity KD=0.15 uM
Affinity_Assay Surface plasmon resonance
PDB_ID 3KYS
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction.
Release_Year 2014
PMID 25221655
DOI 10.1021/ml500160m