PPIRE12541

Target Protein Information
Protein_Name Neuronal acetylcholine receptor subunit alpha-7
Protein_Sequence MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
Organism_Source Rattus norvegicus
Functional_Classification nicotinic acetylcholine receptor
Cellular_Localization Plasma membrane
Gene_Names Chrna7
UniProt_ID Q05941
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name TxIA
Peptide_Sequence GCCSRPPCIANNPDLC
Peptide_Length 16
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CS)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)CN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1662.93
Aliphatic_Index 55.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 2.93750
Charge_at_pH_7 -0.24947
Isoelectric_Point 5.94682
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 25
Topological_Polar_Surface_Area 679.06000
X_logP_energy -9.86733
Interaction Information
Affinity IC50=392 nM
Affinity_Assay two-electrode voltage-clamp electrophysiology
PDB_ID None
Type Ion channel modulator
Structure
Reference Information
Document_Type Research Articles
Title AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity.
Release_Year 2007
PMID 17660751
DOI 10.1038/sj.emboj.7601785