PPIRE12543
Target Protein Information
| Protein_Name | Neuronal acetylcholine receptor subunit alpha-7 |
|---|---|
| Protein_Sequence | MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA |
| Organism_Source | Rattus norvegicus |
| Functional_Classification | nicotinic acetylcholine receptor |
| Cellular_Localization | Plasma membrane |
| Gene_Names | Chrna7 |
| UniProt_ID | Q05941 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | PnIA(A10L) |
|---|---|
| Peptide_Sequence | GCCSLPPCALNNPDYC |
| Peptide_Length | 16 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)CN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1669.92 |
|---|---|
| Aliphatic_Index | 55.00000 |
| Aromaticity | 0.06250 |
| Average_Rotatable_Bonds | 2.81250 |
| Charge_at_pH_7 | -1.25032 |
| Isoelectric_Point | 3.74992 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 26 |
| Number_of_Hydrogen_Bond_Donors | 23 |
| Topological_Polar_Surface_Area | 637.39000 |
| X_logP_energy | -8.18230 |
Interaction Information
| Affinity | IC50=13 nM |
|---|---|
| Affinity_Assay | two-electrode voltage-clamp electrophysiology |
| PDB_ID | None |
| Type | Ion channel modulator |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity. |
| Release_Year | 2007 |
| PMID | 17660751 |
| DOI | 10.1038/sj.emboj.7601785 |