PPIRE12577

Target Protein Information
Protein_Name Urokinase plasminogen activator surface receptor
Protein_Sequence MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDVQYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT
Organism_Source Homo sapiens
Functional_Classification GPI-anchored receptors
Cellular_Localization Plasma membrane
Gene_Names PLAUR
UniProt_ID Q03405
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Clone 48
Peptide_Sequence AEISFSELMWLRSTPAF
Peptide_Length 17
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1985.28
Aliphatic_Index 80.58824
Aromaticity 0.17647
Average_Rotatable_Bonds 3.58824
Charge_at_pH_7 -0.99847
Isoelectric_Point 4.25815
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 27
Topological_Polar_Surface_Area 753.34000
X_logP_energy -4.84753
Interaction Information
Affinity Ki=5 uM
Affinity_Assay radioligand binding assay
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title High-affinity urokinase receptor antagonists identified with bacteriophage peptide display.
Release_Year 1994
PMID 8041758
DOI 10.1073/pnas.91.15.7129