PPIRE12611

Target Protein Information
Protein_Name Anoctamin
Protein_Sequence MRESHKEYADDNEKGIHIINIKAIEDIAYVQSDGMLLNSLGADRDTGCKHGLFFGDGQRKVDYILAFTYKKSSGSRTPHKKNHNSNSVHSLHSPKDDHHLPGGGADLEAMEAEPKMDYHEDDKRFRREEYEGNLIETGLELERDEETKLHGVGFVKIHAPWNVLCREAEFMKLKMPTKKVYHINQTPDLMQKLSSFIQKICEPIQPKVAGLRPQTVKHLSYPFSREKQHLFDMSDKDSFFDSKTRSSIVYEILKRTTCTKAKYSMGITSLLANGVYSAAYPLHDGDYDSEAEANDRKLLCDEWASYSAFYKFQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASVVGIIVFLYGCATVDENIPSMEMCDTRYNITMCPLCDRTCNYWKMSSACGTARASHLFDNPATVFFSVFMALWAATFMEHWKRRQMRLNYRWDLTGFEEEEGMVKDHPRAEYEAKVLQKSLKKEYRNKEKQQHVPEDNPNKWKQRVKTAMAGVKLTEKEKLTWRDRFPAYLTNMVGIIFMIGVTFAIVFGVIIYRISTAAALAMSSNPNTRANVRVTVTATAVIINLVVILILDEVYGAIARWLTQLEVPKTDKTFEERLIFKAFLLKFVNAYTPIFYVAFFKGRIVGRPGDYYYIFQSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKSKRQSYKDHEEHLKKKQRYEEDHNLEPFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFITELRRPVAVRAKDIGIWYNIIRGVGKLAVIINAFVISFTSDFIPRLVYLYMYSPDGTMHGFVNHTLSYFNVSDFKPGNEPTQPVDFGYKVEVCRYKDYREPAWSLNKYDINKDYWAVLAARLAFVIVFQNLVMFMSDFVDWIIPDIPKDISEQIHREKVLVVEVFLKEEQGKLQMLETWKERERKKGENCKSPRLSRSQRGSSASMYCHRADV
Organism_Source Xenopus laevis
Functional_Classification calcium-activated chloride channels
Cellular_Localization Plasma membrane
Gene_Names ano1.S
UniProt_ID A0A8J0V4W0
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Penetratin
Peptide_Sequence CRQIKIWFPNRRMKWKK
Peptide_Length 17
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CS)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2318.88
Aliphatic_Index 45.88235
Aromaticity 0.17647
Average_Rotatable_Bonds 4.64706
Charge_at_pH_7 6.93482
Isoelectric_Point 12.28031
Number_of_Hydrogen_Bond_Acceptors 29
Number_of_Hydrogen_Bond_Donors 35
Topological_Polar_Surface_Area 927.67000
X_logP_energy -4.42619
Interaction Information
Affinity EC50=3.2 uM
Affinity_Assay two-electrode voltage clamp
PDB_ID None
Type Ion channel modulator
Structure
Reference Information
Document_Type Research Articles
Title Penetratin peptide potentiates endogenous calcium-activated chloride currents in Xenopus oocytes.
Release_Year 2011
PMID 21442407
DOI 10.1007/s00232-011-9359-5