PPIRE12623

Target Protein Information
Protein_Name Glutamate receptor ionotropic, NMDA 1
Protein_Sequence MSTMHLLTFALLFSCSFARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYNWNHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQFDPGTKNVTALLMEARELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGIIGLQLINGKNESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTMSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDTSTGGGRGALQNQKDTVLPRRAIEREEGQLQLCSRHRES
Organism_Source Rattus norvegicus
Functional_Classification ion channels
Cellular_Localization Plasma membrane
Gene_Names Grin1
UniProt_ID P35439
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name con-R[1-17]
Peptide_Sequence GEXXVAKMAAXLARXNI
Peptide_Length 17
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)CN)C(C)C)C(=O)O
Chemical_Modification X3=Q-carboxyglutamic acid; X4=Q-carboxyglutamic acid; X11=Q-carboxyglutamic acid; X15=Q-carboxyglutamic acid
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1571.81
Aliphatic_Index 86.47059
Aromaticity 0.00000
Average_Rotatable_Bonds 3.17647
Charge_at_pH_7 0.99946
Isoelectric_Point 9.69503
Number_of_Hydrogen_Bond_Acceptors 23
Number_of_Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 697.23000
X_logP_energy -8.97453
Interaction Information
Affinity IC50=90 nM
Affinity_Assay radioligand competition binding assay
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Structure-function relationships of the NMDA receptor antagonist peptide, conantokin-R.
Release_Year 2000
PMID 10734223
DOI 10.1016/S0014-5793(00)01309-0