PPIRE12646

Target Protein Information
Protein_Name 14-3-3 protein zeta/delta
Protein_Sequence MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN
Organism_Source Homo sapiens
Functional_Classification adaptor proteins
Cellular_Localization Cytoplasm
Gene_Names YWHAZ
UniProt_ID P63104
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name pS-Raf-259
Peptide_Sequence LSQRQRSTXSTPNVHMV
Peptide_Length 17
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@H](C(=O)O)C(C)C
Chemical_Modification X9=phosphoserine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1898.13
Aliphatic_Index 57.05882
Aromaticity 0.00000
Average_Rotatable_Bonds 3.64706
Charge_at_pH_7 2.08889
Isoelectric_Point 12.50011
Number_of_Hydrogen_Bond_Acceptors 30
Number_of_Hydrogen_Bond_Donors 32
Topological_Polar_Surface_Area 903.03000
X_logP_energy -13.95886
Interaction Information
Affinity KD=120 nM
Affinity_Assay not specified
PDB_ID 1A37
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title 14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove.
Release_Year 1998
PMID 9632691
DOI 10.1074/jbc.273.26.16305