PPIRE12660

Target Protein Information
Protein_Name PHD finger protein 1
Protein_Sequence MAQPPRLSRSGASSLWDPASPAPTSGPRPRLWEGQDVLARWTDGLLYLGTIKKVDSAREVCLVQFEDDSQFLVLWKDISPAALPGEELLCCVCRSETVVPGNRLVSCEKCRHAYHQDCHVPRAPAPGEGEGTSWVCRQCVFAIATKRGGALKKGPYARAMLGMKLSLPYGLKGLDWDAGHLSNRQQSYCYCGGPGEWNLKMLQCRSCLQWFHEACTQCLSKPLLYGDRFYEFECCVCRGGPEKVRRLQLRWVDVAHLVLYHLSVCCKKKYFDFDREILPFTSENWDSLLLGELSDTPKGERSSRLLSALNSHKDRFISGREIKKRKCLFGLHARMPPPVEPPTGDGALTSFPSGQGPGGGVSRPLGKRRRPEPEPLRRRQKGKVEELGPPSAVRNQPEPQEQRERAHLQRALQASVSPPSPSPNQSYQGSSGYNFRPTDARCLPSSPIRMFASFHPSASTAGTSGDSGPPDRSPLELHIGFPTDIPKSAPHSMTASSSSVSSPSPGLPRRSAPPSPLCRSLSPGTGGGVRGGVGYLSRGDPVRVLARRVRPDGSVQYLVEWGGGGIF
Organism_Source Homo sapiens
Functional_Classification histone methylation reader
Cellular_Localization Nucleus
Gene_Names PHF1
UniProt_ID O43189
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name H3(19-35)K27me3
Peptide_Sequence QLATKAARKSAPATGGV
Peptide_Length 17
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)O)C(C)C)[C@@H](C)O)[C@@H](C)O
Chemical_Modification K9=trimethylation
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1626.88
Aliphatic_Index 69.41176
Aromaticity 0.00000
Average_Rotatable_Bonds 3.11765
Charge_at_pH_7 2.99739
Isoelectric_Point 11.82306
Number_of_Hydrogen_Bond_Acceptors 25
Number_of_Hydrogen_Bond_Donors 26
Topological_Polar_Surface_Area 737.85000
X_logP_energy -10.73363
Interaction Information
Affinity KD=168 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 2M0O
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting.
Release_Year 2013
PMID 23273982
DOI 10.1016/j.molcel.2012.11.026