PPIRE12675

Target Protein Information
Protein_Name Troponin C, skeletal muscle
Protein_Sequence MTDQQAEARSYLSEEMIAEFKAAFDMFDADGGGDISVKELGTVMRMLGQTPTKEELDAIIEEVDEDGSGTIDFEEFLVMMVRQMKEDAKGKSEEELAECFRIFDRNADGYIDPEELAEIFRASGEHVTDEEIESLMKDGDKNNDGRIDFDEFLKMMEGVQ
Organism_Source Homo sapiens
Functional_Classification EF-hand proteins
Cellular_Localization Cytoplasm
Gene_Names TNNC2
UniProt_ID P02585
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name sTnI115-131
Peptide_Sequence RMSADAMLKALLGSKHK
Peptide_Length 17
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1857.26
Aliphatic_Index 86.47059
Aromaticity 0.00000
Average_Rotatable_Bonds 3.94118
Charge_at_pH_7 3.08845
Isoelectric_Point 11.07954
Number_of_Hydrogen_Bond_Acceptors 28
Number_of_Hydrogen_Bond_Donors 28
Topological_Polar_Surface_Area 775.32000
X_logP_energy -7.43393
Interaction Information
Affinity KD=300 uM
Affinity_Assay 1H NMR spectroscopy
PDB_ID None
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title Energetics of the induced structural change in a Ca2+ regulatory protein: Ca2+ and troponin I peptide binding to the E41A mutant of the N-domain of skeletal troponin C.
Release_Year 2000
PMID 11027154
DOI 10.1021/bi001240u