PPIRE12684

Target Protein Information
Protein_Name Rho guanine nucleotide exchange factor 7
Protein_Sequence MTDNANSQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREIKPSEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETEHEYSKELQSVLSTYLWPLQTSEKLSSANTSYLMGNLEEISSFQQVLVQSLEECTKSPEAQQRVGGCFLSLMPQMRTLYLAYCANHPSAVSVLTEHSEDLGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQEVRKRKELELQILTEPIRSWEGDDIKTLGSVTYMSQVTIQCAGSEEKNERYLLLFPNLLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLHEWVEHLQRQTKVTSVSNPTIKPHSVPSHTLPSHPLTPSSKHADSKPVALTPAYHTLPHPSHHGTPHTTISWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSRSPKTMKKLLPKRKPERKPSDEEFAVRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDEVQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL
Organism_Source Rattus norvegicus
Functional_Classification SH3 domain-containing adaptor proteins
Cellular_Localization Cytoplasm
Gene_Names Arhgef7
UniProt_ID O55043
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Cbl-b peptide
Peptide_Sequence SQAPARPPKPRPRRTAY
Peptide_Length 17
Peptide_SMILES C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1949.25
Aliphatic_Index 17.64706
Aromaticity 0.05882
Average_Rotatable_Bonds 3.23529
Charge_at_pH_7 4.99683
Isoelectric_Point 12.51004
Number_of_Hydrogen_Bond_Acceptors 27
Number_of_Hydrogen_Bond_Donors 30
Topological_Polar_Surface_Area 862.37000
X_logP_energy -10.48522
Interaction Information
Affinity KD=14 mM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 2AK5
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Cbl promotes clustering of endocytic adaptor proteins.
Release_Year 2005
PMID 16228008
DOI 10.1038/nsmb1000