PPIRE12765

Target Protein Information
Protein_Name Somatostatin receptor type 2
Protein_Sequence MELTSEQFNGSQVWIPSPFDLNGSLGPSNGSNQTEPYYDMTSNAVLTFIYFVVCVVGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMINVAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPTPALKGMFDFVVILTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGAEDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
Organism_Source Rattus norvegicus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names Sstr2
UniProt_ID P30680
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name HYNIC-TOC2
Peptide_Sequence EfCYwKTCXfCYwKTCX
Peptide_Length 17
Peptide_SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)[C@@H](C)O)C(=O)N[C@@H](CS)C(=O)NCC(=O)O
Chemical_Modification X9=Thr(ol); X17=Thr(ol)
Cyclization_Method Side chain cyclization; C2<->C7; disulfide bond; C11<->C16; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Hynic
C-terminal_Modification threoninol
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2125.48
Aliphatic_Index 0.00000
Aromaticity 0.35294
Average_Rotatable_Bonds 3.64706
Charge_at_pH_7 0.74957
Isoelectric_Point 7.90856
Number_of_Hydrogen_Bond_Acceptors 29
Number_of_Hydrogen_Bond_Donors 31
Topological_Polar_Surface_Area 730.76000
X_logP_energy -3.14850
Interaction Information
Affinity IC50=0.74 nM
Affinity_Assay competitive radioligand binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title (99m)Tc-labeled dimeric octreotide peptide: a radiotracer with high tumor uptake for single-photon emission computed tomography imaging of somatostatin receptor subtype 2-positive tumors.
Release_Year 2013
PMID 23768172
DOI 10.1021/mp400040z