PPIRE12794

Target Protein Information
Protein_Name Acetylcholine-binding protein
Protein_Sequence MRRNIFCLACLWIVQACLSLDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTTENSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGRSEIL
Organism_Source Lymnaea stagnalis
Functional_Classification ligand gated ion channel
Cellular_Localization Extracellular
Gene_Names None
UniProt_ID P58154
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name MII
Peptide_Sequence GCCSNPVCHLEHSNLC
Peptide_Length 16
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)CN)C(C)C)C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1715.95
Aliphatic_Index 66.87500
Aromaticity 0.00000
Average_Rotatable_Bonds 3.25000
Charge_at_pH_7 -1.06632
Isoelectric_Point 6.46666
Number_of_Hydrogen_Bond_Acceptors 28
Number_of_Hydrogen_Bond_Donors 27
Topological_Polar_Surface_Area 712.33000
X_logP_energy -10.19290
Interaction Information
Affinity Ki=1093 nM
Affinity_Assay competitive radioligand binding assay
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity.
Release_Year 2007
PMID 17660751
DOI 10.1038/sj.emboj.7601785