PPIRE12820

Target Protein Information
Protein_Name Telomeric repeat-binding factor 2
Protein_Sequence MAAGAGTAGPASGPGVVRDPAASQPRKRPGREGGEGARRSDTMAGGGGSSDGSGRAAGRRASRSSGRARRGRHEPGLGGPAERGAGEARLEEAVNRWVLKFYFHEALRAFRGSRYGDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKALKSESAASSTGKEDKQPAPGPVEKPPREPARQLRNPPTTIGMMTLKAAFKTLSGAQDSEAAFAKLDQKDLVLPTQALPASPALKNKRPRKDENESSAPADGEGGSELQPKNKRMTISRLVLEEDSQSTEPSAGLNSSQEAASAPPSKPTVLNQPLPGEKNPKVPKGKWNSSNGVEEKETWVEEDELFQVQAAPDEDSTTNITKKQKWTVEESEWVKAGVQKYGEGNWAAISKNYPFVNRTAVMIKDRWRTMKRLGMN
Organism_Source Homo sapiens
Functional_Classification telomeric repeat-binding factors
Cellular_Localization Nucleus
Gene_Names TERF2
UniProt_ID Q15554
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name RAP1-YLP
Peptide_Sequence ENRERLELEAYRLGPASA
Peptide_Length 18
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CCC(=O)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2074.28
Aliphatic_Index 81.66667
Aromaticity 0.05556
Average_Rotatable_Bonds 3.83333
Charge_at_pH_7 -0.99578
Isoelectric_Point 4.62819
Number_of_Hydrogen_Bond_Acceptors 29
Number_of_Hydrogen_Bond_Donors 34
Topological_Polar_Surface_Area 967.68000
X_logP_energy -9.95949
Interaction Information
Affinity KD=13 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 4RQI
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title A higher-order entity formed by the flexible assembly of RAP1 with TRF2.
Release_Year 2016
PMID 26748096
DOI 10.1093/nar/gkv1531